Education

 

Ph.D. (expected), Bioinformatics and Computational Biology, Iowa State University, 2007

M.S., Statistics, Iowa State University, 2005

M. Phil., Biochemistry, Chinese University of Hong Kong, 2001

B.S., Biology, University of Science and Technology of China, 1998

B. Eng., Economics and Management, University of Science and Technology of China, 1998

 

Teaching Experience

 

Teaching Assistant, Survey of Biochemistry (BBMB 301), Iowa State University, Spring 2006 and Fall 2006

Teaching Assistant, Molecular Biotechnology (MBT 4031), Chinese University of Hong Kong, Spring 2000 and Spring 2001

Teaching Assistant, Environmental Science (ENS 4251), Iowa State University

Chinese University of Hong Kong, Spring 2000

 

Research Interests

 

Bioinformatics and computational structural biology: study the relationship of protein structures, motions and functions using various methods such as elastic network model (ENM) and molecular dynamics (MD); generate the feasible transition pathways between different conformations of the same protein; study protein-ligand binding and protein docking problems and their biopharmaceutical applications.

 

Biostatistics: build the large dataset for studying protein motions and conformational transitions and evaluate the dataset using various statistical approaches; use principal component analysis to study protein motions by reducing the dimensionality of system (e.g. analyze MD data using essential dynamics); conduct statistical analysis of protein structural and sequence data and interpret findings.

 

  

Skills

 

Matlab, Perl, VC++, SAS, R / S-Plus, MS Office, LaTeX.

 

Publications

 

S. Avasarala, L. Yang, Y. Sun, A. W. C. Leung, W. Y. Chan, W. T. Cheung and S. S. T. Lee. A temporal study on the histopathological, biochemical and molecular responses of CCl 4 -induced hepatotoxicity in Cyp2e1-null mice. Toxicology, 2006, 228:310-322.

 

2. L. Yang, G. Song and R. L. Jernigan. How well can we understand large-scale protein motions using normal modes? (Submitted to Biophys. J.)

 

3. L. Yang. How to build WWW and FTP service with dynamic IP, Computer (in Chinese), 1998,12:34.

 

Manuscripts in Preparation

 

1. L. Yang, G. Song, A. Carriquiry and R. L. Jernigan. Identification of essential protein motions from principal component analysis of multiple HIV-1 protease structures and agreement with elastic network modes.

 

2. G. Song, L. Yang and R. L. Jernigan. Studying protein anisotropic B-factors using anisotropic network model.

 

3. L. Yang, G. Song and R. L. Jernigan. Exploring the Dynamics of Proteins from NMR Structures and Evaluating the Dynamics Predicted by ANM.

 

Presentations

 

1. L. Yang, G. Song, A. Carriquiry and R. L. Jernigan. Identification of essential protein motions from principal component analysis of multiple HIV-1 protease structures and agreement with elastic network modes. The 20th Annual Symposium of The Protein Society & 20th Anniversary Celebration, August 2006, San Diego, CA, USA.

 

2. L. Yang, G. Song, A. Carriquiry and R. L. Jernigan. Identifying essential protein motions from principal component analysis of multiple HIV-1 protease structures and agreement with elastic network modes. The 32nd Steenbock Symposium - Dynamics of Proteins and Macromolecular Assemblies, May 2006, Madison, WI, USA.

 

3. L. Yang, G. Song, X. Zhao, A. Carriquiry and R. Jernigan. Motion analysis of HIV-1 protease by anisotropic network model and principal component analysis. Growth Factors and Signal Transduction Symposium - Integration of Structural and Functional Genomics, September 2005, Ames, USA.

 

4. L. Yang, G. Song, X. Zhao, A. Carriquiry and R. Jernigan. Motion analysis of HIV-1 protease by anisotropic network model and principal component analysis. The 5th Annual Joint Bioinformatics Workshop between UI and ISU, July 2005, Ames, USA.

 

5. L. Yang, L. Tian and S. T. Lee. Identification of CYP2E1 dependent genes involved in carbon tetrachloride (CCl4) and acetaminophen (APAP) induced hepatotoxicity. The 13th International Symposium on Microsomes and Drug Oxidations (MDO2000). July 2000, Stresa, Italy.

 

6. L. Tian, L. Yang, W. T. Cheung, D. S. C. Tsang, D. C. C. Wan, W. Y. Chan and S. T. Lee. Differential display analysis of peroxisome proliferator-activated receptor alpha (PPARa) dependent genes involved in the cellular fasting response. The 13th International Symposium on Microsomes and Drug Oxidations (MDO2000), July 2000, Stresa, Italy.